The Effects of Hyperthyroidism on Lipid Peroxidation, Erythrocyte Glutathione and Glutathione Peroxidase

ABSTRACT
Previous studies have suggested that hyperthyroidism has some effects on lipid peroxidation and antioxidant systems. This study was designed to determine if lipid peroxid ation, glutathione, and glutathione peroxidase can be modified by hyperthyroidi sm. 23 subjects with hyperthyroidism (18 females / 5 males), and 19 euthyroid subjects (11 females / 8 males) participated in this study. Plasma and erythrocytes malondialdehyde, erythrocytes glutathione and glutathione peroxidase were measured . An increase in lipid peroxidation products was observed in the hyperthyroid patients (p< 0.001). This was accompanied by a decrease in glutathione and glutathione peroxidase in the same subjects (p< 0.001). The results suggested that hyperthyroidism has some effects on lipid peroxidation and free radical scavengers.