Endocrinology Research and Practice
Original Article

The Effects of Coenzyme Q10 (CoQ10) on Ionizing Radiation- Induced Pancreatic β-Cell Injury


Department of Endocrinology and Metabolism Disease, Recep Tayyip Erdoğan University, Faculty of Medicine, Rize, Turkey


Department of Histology and Embryology, Recep Tayyip Erdoğan University, Faculty of Medicine, Rize, Turkey


Department of Radiation Oncology, Recep Tayyip Erdoğan University, Faculty of Medicine, Rize, Turkey

Endocrinol Res Pract 2023; 27: 127-134
DOI: 10.5152/erp.2023.23245
Read: 1734 Downloads: 411 Published: 01 July 2023

Objective: This study investigated the antioxidant effect of coenzyme Q10 on ionizing radiation- induced oxidative damage in pancreatic β-cells.

Methods: Twenty-four male rats were assigned to 4 groups. Group 1 constituted the control group, Group 2 only received a single i.p. dose of coenzyme Q10, Groups 3 and 4 received a total of 4 Gy external x-ray radiation to the abdomen in a single fraction. Group 4 also received a single dose of 200 mg/kg coenzyme Q10 i.p. 30 minutes prior to x-ray irradiation.

Results: The x-ray radiation group showed decreased β-cell positivity in the islets of Langerhans com- pared to the control group on immunohistochemical analysis. In contrast, an increase in β-cells exhib- iting insulin positivity was observed in group 4 (ionizing radiation + coenzyme Q10) compared to the irradiation group. Terminal deoxynucleotidyl transferase dUTP nick end labeling assay indicated a rise in the number of apoptotic cells in the x-ray radiation group compared to the control and coenzyme Q10-only groups (Group 2). Meanwhile, we observed a decrease in the number of terminal deoxy- nucleotidyl transferase dUTP nick end labeling-positive apoptotic cells in the islets of Langerhans in the ionizing radiation + coenzyme Q10 treatment group (Group 4) relative to the irradiation group.

Conclusion: This study shows that coenzyme Q10 reduces apoptosis in the rat pancreas exposed to abdominal ionizing radiation.

Cite this article as: Mercantepe F, Tümkaya L, Mercantepe T, Yılmaz Rakıcı S. The effects of coenzyme Q10 (CoQ10) on ionizing radiation-induced pancreatic β-cell injury. Endocrinol Res Pract. 2023;27(3):127-134.

EISSN 2822-6135