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ABSTRACT
Pseudohypoaldosteronism (PHA) i s characterised by salt wasting and failure to thrive in the newborn because of the resistance of mineralocorticoid receptors to aldosterone. The diagnosis is based on dehydration, hyponatremia, hyperkalemia, high urine sodium, and high serum concentrations of aldosterone and renin. The hyponatremia in PHA is not improved by exogenous mineralocorticoid administration without added sodium chloride. In this paper we reported two cases whose clinical and laboratory findings were compatible with the classical PHA. The hyponatremia of the cases was improved only by exogenous sodium chloride supplementation to their diets.
Pseudohypoaldosteronism (PHA) i s characterised by salt wasting and failure to thrive in the newborn because of the resistance of mineralocorticoid receptors to aldosterone. The diagnosis is based on dehydration, hyponatremia, hyperkalemia, high urine sodium, and high serum concentrations of aldosterone and renin. The hyponatremia in PHA is not improved by exogenous mineralocorticoid administration without added sodium chloride. In this paper we reported two cases whose clinical and laboratory findings were compatible with the classical PHA. The hyponatremia of the cases was improved only by exogenous sodium chloride supplementation to their diets.