Congenital Hypothyroidism and Hyperinsulinaemic Hypoglycaemia - Case Report

Abstract
Congenital hypothyroidism is one of the most common endocrine disorders observed in paediatric endocrinology. Thyroid hormones play an important role in glucose physiology and in determining tissue insulin sensitivity. Hyperinsulinaemic hypoglycaemia is a major cause of hypoglycaemia in the neonatal period and can be congenital or secondary to intrauterine growth retardation, perinatal asphyxia and maternal diabetes mellitus. We report a newborn with congenital hypothyroidism due to dyshormonogenesis and severe hyperinsulinaemic hypoglycaemia. The hyperinsulinaemic hypoglycaemia corrected when replacement therapy with thyroxine was commenced. In this report, it is emphasized that hypoglycemia in neonatal period may be an unusual finding in congenital hypothyroidism.