Androgen Secreting Adrenocortical Carcinoma and its Treatment By Open Adrenalectomy in Two Years Old Boy - Case Report

Abstract
Adrenal tumors that secrete sex hormones are quite rare, but are nearly always symptomatic. Approximately one-half of virilizing tumors and nearly all feminizing tumors are malignant. We report a rare case of a 2-year-old boy who presented with virilization and was diagnosed with an adrenal cortical carcinoma. Serum dehydroepiandrostenedione sulfate level was as high as 26 µmol/L, testosterone level was 36.22 nmol/L. Magnetic resonance imaging of the abdomen revealed a large mass in his left adrenal gland measuring 10x10x10 cm. Tumor was successfully resected by open adrenalectomy, thus it was not given a chemotherapeutic agent. Postoperatively, androgen levels returned to normal ranges. In the presence of elevated levels of dehydroepiandrostenedione sulfate and testosterone the diagnosis of adrenocortical tumor can be made with near certainty, its early recognition and surgical resection are important for a good prognosis.