Endocrinology Research and Practice
Original Article

Use of Metformin in Pregnancy: A Survey of Turkish Physicians' Attitudes - Original Article


Dokuz Eylül University Medical School, Department of Internal Medicine, Division of Endecrinology and Metabolism, Izmir, Turkey


Dokuz Eylül University, Internal Medicine, İzmir, Turkey


Dokuz Eylul University, School of Medicine, Division of Endocrinology and Metabolism, Department of Internal Medicine, İzmir, Turkey


Dokuz Eylül University Medical School, Division of Endocrinology, İnciraltı, Izmir

Endocrinol Res Pract 2009; 13: 25-28
Read: 1630 Downloads: 360 Published: 01 June 2009

 Although metformin crosses the placenta, there is no current evidence whether the use of metformin in pregnancy is associated with increased risk of fetal and maternal complications. The aim of this present study is to investigate the attitudes of Turkish physicians in different specialties in terms of metformin use in pregnancy.
Materials and Methods: Current opinions were assessed by a questionnaire. Nine hundred forty physicians were invited to join the study; however, completely fulfilled questionnaires could be obtained from a total of 407 physicians (170 family physicians, 139 internists and 98 obstetricians).
Results: One hundred fifty-one physicians (37.1%) stated that they recommended metformin use in pregnancy for any of the indications (pregnant women with PCOS, type-2 diabetes or gestational diabetes). Obstetricians were more likely to suggest metformin use in pregnancy rather than other physicians. Metformin use in pregnancy was seldom recommended by internists. The rationales of physicians for the metformin use were: lower risk for abortion, decreased prevalence of maternal and neonatal complications, improvement in insulin resistance, prevention of excess weight gain, better glycemic control in diabetics and decreased insulin need in  diabetics taking insulin.
Conclusions: Despite limited data on metformin use in pregnancy, significant number of physicians in Turkey supported the metformin use. Obstetricians were the ones most likely to recommend metformin treatment in pregnancy. 


EISSN 2822-6135