Transient Pseudohypoparathyroidism Manifested as Recurrent Convulsion in a Neonate

ABSTRACT

We report case of a neonate who presented with recurrent seizure attacks at the age of 12 days. The baby was managed with anticonvulsant drugs. Eighteen days later, the neonate had repeated episodes of convulsion and was referred to our clinic. During initial work-up, we detected hypocalcaemia and started calcium supplementation along with anticonvulsants. There was another episode of convulsion after 3 days, which prompted us to do a repeat serum calcium assay. It showed hypocalcaemia which was persistent and resistant to calcium supplementation. On further investigation, hyperphosphatemia and raised concentration of parathyroid hormone were detected. Serum magnesium and 25(OH)D level was normal. We suspected pseudohypoparathyroidism-and-hypocalcaemia was managed with calcium and vitamin D therapy. There was no further episode of convulsion and the baby was stable with corrected serum calcium and phosphorus levels during follow-up.