Thyrotoxicosis-Associated Cholestasis in a Patient with Hepatitis B Ci r r h o s i s

Abstract
Abnormalities in liver function tests were reported in association with hyperthyroidism. Intrahepatic cholestasis is one form of this association. Reversal of hyperbilirubinemia upon correction of hyperthyroidism supports the causal relationship. Most reported cases have occurred in patients without previous liver disease. We report a case of marked cholestatic jaundice associated with hyperthyroidism caused by toxic adenoma in a patient with hepatitis B cirrhosis. Serum bilirubin returned to baseline level after correcting hyperthyroidism with radioiodine therapy. Hyperthyroidism should be considered in the differential diagnosis of cholestasis in association with chronic liver disease.