Thirty-Four Patients with Cushing's Syndrome: Our Clinical Experience in the Past 20 Years - Original Article

Abstract
Objective: Cushing's syndrome is a relatively rare disorder caused by chronic endogenous hypercortisolemia. We aimed to present patients with Cushing's syndrome who were diagnosed and followed at our endocrinology clinic. 
Materials and Methods: 34 patients (26 female, 8 male) with Cushing's syndrome were enrolled in this retrospective study.
Results: Of 34 patients, 20 had Cushing's disease and 14 had Cushing's syndrome. Regarding the clinical signs of Cushing's syndrome, purple striae were present in 31 subjects (91.2%), hirsutismus in 21 (72.4 %), buffalo hump in 33 (97.1%), moon face in 33 (%97.1), plethora in 33 (%97.1), and menstrual irregularities in 21 (84%) subjects. Diabetes mellitus (DM), hypertension and osteoporosis were found to be 13/34 (39.4%), 23/34 (69.7%) and 18/34 (66.7%), respectively. Following the treatment, primary adrenal failure, secondary adrenal failure, central hypothyroidism, central hypogonadism and central diabetes insipidus were found to be 3 (8.8%), 3 (8.8%), 4 (11.7%), 4 (11.7%) and 4 (11.7%), respectively.
Conclusions: As reported in the literature, Cushing's disease is the most common form of Cushing's syndrome and various complications such as adrenal failure, hypogonadism, diabetes insipidus can develop following the treatment.