Endocrinology Research and Practice
Original Article

Thirty-Four Patients with Cushing's Syndrome: Our Clinical Experience in the Past 20 Years - Original Article


Çukurova University Faculty of Medicine, Department of Endocrinology, Adana, Turkey


Çukurova University Medical Faculty, Department of Internal Medicine, Endocrinology Division, Adana, Turkey

Endocrinol Res Pract 2009; 13: 75-79
Read: 1116 Downloads: 288 Published: 01 December 2009

 Cushing's syndrome is a relatively rare disorder caused by chronic endogenous hypercortisolemia. We aimed to present patients with Cushing's syndrome who were diagnosed and followed at our endocrinology clinic. 
Materials and Methods: 34 patients (26 female, 8 male) with Cushing's syndrome were enrolled in this retrospective study.
Results: Of 34 patients, 20 had Cushing's disease and 14 had Cushing's syndrome. Regarding the clinical signs of Cushing's syndrome, purple striae were present in 31 subjects (91.2%), hirsutismus in 21 (72.4 %), buffalo hump in 33 (97.1%), moon face in 33 (%97.1), plethora in 33 (%97.1), and menstrual irregularities in 21 (84%) subjects. Diabetes mellitus (DM), hypertension and osteoporosis were found to be 13/34 (39.4%), 23/34 (69.7%) and 18/34 (66.7%), respectively. Following the treatment, primary adrenal failure, secondary adrenal failure, central hypothyroidism, central hypogonadism and central diabetes insipidus were found to be 3 (8.8%), 3 (8.8%), 4 (11.7%), 4 (11.7%) and 4 (11.7%), respectively.
Conclusions: As reported in the literature, Cushing's disease is the most common form of Cushing's syndrome and various complications such as adrenal failure, hypogonadism, diabetes insipidus can develop following the treatment. 



EISSN 2822-6135