The Relationship Between the Level of Parathormone and the Existence and the Degree of Coronary Atherosclerosis

ABSTRACT

Objective: An elevated level of parathormone, which is the major regulator of bone and mineral metabolism, has detrimental effects on the heart and vascular system. In this study, we investigated the relationship between the risk and degree of coronary atherosclerosis and parathormone levels.

Material and Methods: A total number of 77 patients were included in the study. Serum levels of parathormone, calcium, albumin, phosphorus, and 25-OH vitamin D were analyzed in the samples collected pre-operatively from the patients who underwent elective coronary angiography. The severity and diffusiveness of coronary atherosclerosis were calculated from the angiographic images using Gensini score. Pearson's correlation test and logistic regression were used to analyze the correlation between parathormone levels and the Gensini scores.

Results: No significant relationship was observed between PTH values and Gensini scores. When the patients’ Gensini scores were grouped as smaller and greater than 20 and then compared with the other variables individually, a positive correlation with the corrected calcium levels and 25-OH vitamin D levels was observed. In multivariate analysis, none of the compared variables showed a relationship with Gensini score. Lastly, when the patients were divided by the parathormone levels into three tertiles and compared with Gensini scores, no significant relationship was observed.

Conclusion: No relationship was observed between the parathormone levels and coronary atherosclerosis variables indicating that parathormone may not affect coronary atherosclerosis.