The Level of Serum High Sensitive C-Reactive Protein in Women with Hyperthyroidism

Abstract

High-sensitive C-reactive protein (hs-CRP) levels, a marker of subclinical inflammation, have been identified as an independent predictor of atherosclerosis. Although it is well known that thyroid hormones play an important role in cardiovascular hemodynamics, the association between elevated thyroid hormones and low grade inflammation is still unclear. We aimed to investigate the serum hs- CRP in women patients with hyperthyroidism. Twenty-five women with hyperthyroidism and 25 healthy-control subjects who were age (31.3±12.3 years, 29.6±7.7 years respectively, p> 0.05) and body mass indexmatched (24.0±3.6 kg/m2, 24.3±4.5 kg/m2, p> 0.05) were included into this study. Patients were evaluated at the time of diagnosis. Serum concentrations of free T4 (fT4), fT3, TSH, and lipid parameters (total cholesterol, triglyceride, high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C) were measured in all subjects. Serum hs-CRP levels were assessed by ELISA method. Mean total cholesterol and LDL-C levels of hyperthyroid group were lower than control group (p= 0.001, p< 0.01). There were no statistically significant differences in hs-CRP levels between hyperthyroid and control groups (0.05±0.032 mg/l, 0.04±0.038 mg/l, p> 0.05; 2.3±1.5, 1.4±0.5, p> 0.05, respectively) and also had not been found any correlation between levels of hs-CRP and thyroid hormones. In this study, these results shown that the elevated thyroid hormones have no effect on the serum hs-CRP level. We conclude that hyperthyroidism do not induce low grade inflammation of atherosclerosis in women.