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ABSTRACT
Adrenocortical carcinoma (ACC) is a rare malignant tumor which is more common in women and hirsutism may be an early sign of the disease. Hİgh DHEAS level is considered as the hallmark of the disease. in this study we have evaluated the hormonal and some of the clinical features of four women with ACC. Three patients had rapid onset hirsutism, al! had hypokalemia and remarkably high serum 11-deoxycortisol levels assoclated with high testosterone levels. On the other hand 2 patients had normal serum DHEAS levels and öne patient interestingly had dexamethasone suppressible DHEAS level. Only patients with high 17-hydroxyprogesterone level had increased DHEAS level which indicates steroidogenic defect is not uniform in patients with ACC. Also, we think that 11-deoxycortisol level may be more important than DHEAS level in the prediction of ACC.
Adrenocortical carcinoma (ACC) is a rare malignant tumor which is more common in women and hirsutism may be an early sign of the disease. Hİgh DHEAS level is considered as the hallmark of the disease. in this study we have evaluated the hormonal and some of the clinical features of four women with ACC. Three patients had rapid onset hirsutism, al! had hypokalemia and remarkably high serum 11-deoxycortisol levels assoclated with high testosterone levels. On the other hand 2 patients had normal serum DHEAS levels and öne patient interestingly had dexamethasone suppressible DHEAS level. Only patients with high 17-hydroxyprogesterone level had increased DHEAS level which indicates steroidogenic defect is not uniform in patients with ACC. Also, we think that 11-deoxycortisol level may be more important than DHEAS level in the prediction of ACC.