Endocrinology Research and Practice
Original Article

The Antibody Response to Endoplasmic Reticulum Stress in Hashimoto's Thyroiditis

1.

Çanakkale Onsekiz Mart University Faculty of Medicine, Department of Endocrinology and Metabolism, Çanakkale, Turkey

2.

Ankara University Faculty of Medicine, Department of Endocrinology and Metabolic Diseases, Ankara, Turkey

3.

Trabzon Training and Research Hospital, Endocrinology and Metabolism, Trabzon, Turkey

4.

Başkent University Faculty of Medicine, Department of Biochemistry, Antalya, Turkey

5.

Adana Education and Research Hospital, Department of Endocrinology and Metabolism, Adana, Turkey

6.

Keçiören Education and Research Hospital, Department of Endocrinology and Metabolism, Ankara, Turkey

7.

Başkent University Faculty of Medicine, Department of Endocrinology and Metabolism, Ankara, Turkey

Endocrinol Res Pract 2013; 17: 53-56
DOI: 10.4274/Tjem.2151
Read: 2303 Downloads: 649 Published: 01 September 2013

ABSTRACT

Purpose: We aimed to investigate the presence of antibodies (Anti-BIP) against binding immunoglobulin protein (BIP), an endoplasmic reticulum (ER) chaperone with immune modulator and anti-apoptotic effects in Hashimoto’s thyroiditis (HT) patients.
Material and Method: We included sixty-two autoimmune thyroiditis patients, 20 with euthyroid autoimmune thyroiditis, 27 with subclinical hypothyroidism and 15 with hypothyroid, and a control group of 37 healthy subjects.
Results: No statistically significant difference was determined in anti-BIP levels among the HT subgroups or in comparison with the control group (p=0.889).
Discussion: Although BIP activation has been shown in vitro in thyroid cells, no difference was determined in our study in anti-BIP levels between the HT patient subgroups and the control group. This suggests that antibodies developing against BIP through apoptosis and/or T cell response are either not related to HT or at levels that cannot be determined by measuring serum. 

 

 

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