Serum Heart Type Fatty Acid Binding Protein Levels in Primary Hyperparathyroidism

ABSTRACT

Purpose: Recent studies indicate that plasma heart-type fatty acid binding-protein (H-FABP) concentration can be used as an early biochemical marker for macrovascular diseases. Patients with primary hyperparathyroidism (PHT) reportedly display an increase in cardiovascular (CV) risk factors. Our aim was to evaluate plasma H-FABP concentration in these subjects with primary hyperparathyroidism, by comparing them with healthy controls.

Material and Method: Anthropometric parameters, serum H-FABP, serum lipid, serum calcium, phosphorus, parathormone (PTH), insulin resistance (HOMA-IR), high sensitive C-reactive protein (h-CRP), 24-hour urine microalbumin excretion and carotid intima-media thickness (CIMT) were evaluated among primary hyperparathyroidism patients (8 males, 80 females) and 87 healthy subjects (12 males, 75 females). Results: No significant difference was seen in the levels of H-FABP between patients [1086.07 (298-3744)] and controls [1113.36 (263.27-3510)]. The average values of PTH, HOMA-IR, total cholesterol, LDL cholesterol, triglycerides and calcium and mean CIMT were found to be significantly higher in patients with primary hyperparathyroidism (p<0.05). H-FABP was positively correlated with age, fasting blood glucose, BMI, and HsCRP.

Discussion: H-FABP levels correlated with some of the CV risk factors like age, fasting blood glucose, BMI, and h-CRP, moreover no difference in H-FABP levels was seen among patients of primary hyperparathyroidism having no cardiac disease.