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ABSTRACT
The goal of this study is to assess the relationship between leptin and bone metabolism and to elucidate whether short term weight reduction influences this relationship. Twenty obese premenopausal women with a mean age of 32.8 years and a mean body mass index (BMI) of 32.8 kg/ m2 were followed for 4.25 (3-5.5) months. The patients followed a moderate energy restricted diet and regular exercise for weight reduction. BMI, plasma leptin, bone specific alkaline phosphatase (B-ALP), osteocalcin (OC), type 1 collagen (PICP) and urine deoxypyridinoline (DPD) levels were measured at baseline and at follow-up visit. Bone mineral density (BMD) measurements were done with dual energy X-ray absorptiometry. At the end of the study, the mean BMI decreased significantly to 31.2 kg/m2 (p=0.006) and serum leptin levels had a tendency to decrease (p=0.168). BALP, OC, PICP levels, urine DPD levels and BMD of femur, lumbar vertebrae and radius did not change significantly at the end of the study. There was no relationship between leptin levels and BMI, markers of bone formation and resorption and BMD at baseline. Despite a reduction in BMI, changes in leptin did not correlate with any bone turnover marker. Our results suggest that leptin has no association with bone metabolism and bone density in obese premenopausal women.
The goal of this study is to assess the relationship between leptin and bone metabolism and to elucidate whether short term weight reduction influences this relationship. Twenty obese premenopausal women with a mean age of 32.8 years and a mean body mass index (BMI) of 32.8 kg/ m2 were followed for 4.25 (3-5.5) months. The patients followed a moderate energy restricted diet and regular exercise for weight reduction. BMI, plasma leptin, bone specific alkaline phosphatase (B-ALP), osteocalcin (OC), type 1 collagen (PICP) and urine deoxypyridinoline (DPD) levels were measured at baseline and at follow-up visit. Bone mineral density (BMD) measurements were done with dual energy X-ray absorptiometry. At the end of the study, the mean BMI decreased significantly to 31.2 kg/m2 (p=0.006) and serum leptin levels had a tendency to decrease (p=0.168). BALP, OC, PICP levels, urine DPD levels and BMD of femur, lumbar vertebrae and radius did not change significantly at the end of the study. There was no relationship between leptin levels and BMI, markers of bone formation and resorption and BMD at baseline. Despite a reduction in BMI, changes in leptin did not correlate with any bone turnover marker. Our results suggest that leptin has no association with bone metabolism and bone density in obese premenopausal women.