Relation Between Leptin and Insulin in Patients with Type 2 Diabetes Mellitus

Abstract

Leptin and insulin are reported to control glucose metabolism therefore, a relationship between these two hormones should reveal the metabolic effect of these hormones on glucose metabolism. In this study, the relationship between leptin and insulin was evaluated in obese diabetes type 2, BMI>30 kg/m2 (group A), and nonobese diabetes type 2 patients, BM<25kg/ m2 (Group B).
Study design: 49 subjected were studied. Of these, 32 subjects (4 male and 28 female) were (group A) and 17 subjects (8 male and 9 female) were (group B) and analyzed for Leptin, Insulin, and HbA1c.
Results: The results obtained showed leptin, insulin and HbA1c levels of 5.16± 1.2 μg/ L and 21.8±11.2 μg/L, 6.75±1.2 μIu/ml and 10.4 μIu/ml and %9.38 ± 0.56 and %8.76 ± 0.36 in groups B and groups A, respectively.
Discussion: The results of this study show that plasma concentrations increased with the percentage of body fat and to body mass index. Plasma leptin in obese diabetes, in comparison to non-obese diabetes individuals, was four times higher (p=0.001). Statistical analysis indicates a direct correlation between fasting blood leptin and insulin (r=0.290 p=0.005) in group B, while this correlation is reverse in group A.