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Objective: Maturity-onset diabetes of the young (MODY) is an uncommon type of diabetes distinct from type 1 and type 2 diabetes. Diagnosis often depends on clinical suspicion, and misdiagnosis may lead to inappropriate treatment. Obesity and dyslipidemia are increasing in diabetic patients, but the prevalence of obesity and dyslipidemia in this group remains unclear. This study aims to evaluate these conditions in MODY patients.
Methods: A descriptive study involving 108 MODY patients and 108 healthy controls was conducted. Clinical data were collected and analyzed, including body mass index (BMI), fasting plasma glucose, HbA1c, and lipid profile. Statistical comparisons were made between the MODY and control groups to assess the prevalence of obesity and dyslipidemia. Further subgroups, including obesity and dyslipidemia, were analyzed to explore the relationship between these metabolic conditions and clinical parameters within the MODY cohort.
Results: The study revealed a significantly higher prevalence of both obesity and dyslipidemia in MODY patients compared to controls. Specifically, 24.1% of MODY patients were found to be obese, while 72.2% exhibited dyslipidemia. Notably, obese MODY patients had elevated triglyceride levels compared to their non-obese counterparts. Additionally, it was determined that dyslipidemic MODY patients were older, had higher BMI, and exhibited poorer glycemic control. Increased age and obesity were found to be significantly associated with dyslipidemia in MODY patients, according to the regression analysis.
Conclusion: The current study demonstrates that the rate of obesity and dyslipidemia is high among MODY patients, and these conditions may negatively impact the course of the disease.
Cite this article as: Calapkulu M, Ozturk Unsal I, Erkam Sencar M, Sakiz D, Ozbek M, Cakal E. Prevalence of obesity and dyslipidemia in maturity onset diabetes of the young patients. Endocrinol Res Pract. 2025;29(1):9-14.