Mean Platelet Volume in Various Degrees of Disturbed Carbohydrate Metabolism

ABSTRACT

Purpose: Mean platelet volume (MPV) has shown to be increased in patients with Type 2 diabetes mellitus (T2DM) and to be related with increased cardiovascular risk. It is not clear how MPV is affected in prediabetes. We evaluated MPV in patients who have varying degrees of disturbed carbohydrate metabolism.
Material and Method: Among the patients who attended our endocrinology outpatient clinic between June 2009 and May 2010, 510 patients who underwent oral glucose tolerance test (OGTT) for evaluation of obesity and suspected type 2 diabetes mellitus(T2DM) and 780 T2DM patients with regular follow-up were included in this cross-sectional study. The prediabetic patients (n=142) were grouped according to their OGTT. Group 1 (n=52) had normal OGTT, group 2 (n=57) had impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) with one-hour plasma glucose <200 mg/dl, group 3 (n=33) had one-hour plasma glucose ≥200 mg/dl in addition to IFG and/or IGT and, group 4 included age-, gender- and body composition-matched patients with T2DM. 
Results: Groups 2 and 3 had higher low-density lipoprotein cholesterol (LDL-K) levels than T2DM group. The level of high-density lipoprotein cholesterol (HDL-C) in group 4 was lower than in the other three groups. T2DM group had the highest MPV when compared with the other three groups, but MPV did not differ between the groups performing OGTT. MPV increased in patients with T2DM when compared with both control and prediabetic groups. MPV did not change in both patients with prediabetes and prediabetes with one-hour plasma glucose ≥200 mg/dl. These findings may be due to shorter period and relatively lower levels of hyperglycemia and inexistence of vascular complications in state of prediabetes when compared to T2DM.