Macroprolactinemia Associated with Anti-Prolactin Antibodies: A Case Report

ABSTRACT
Macromolecular form of prolactin is generally associated with asymptomatic hyperprolactinemia. Increases in molecular size may result from self-aggregation or binding with antiprolactin antibodies. Such a benign clinically insignificant laboratory abnormality could be documented by gel filtration chromatography, polyethylene glycol precipitation methods or directly detecting antiprolactin autoantibody itself. Here we report a case of asymptomatic hyperprolactinemia due to macroprolactinemia associated with prolactin autoantibodies to notice the importance of clinically insignificant isolated laboratory abnormalities.