Lipid Profile in the Elderly and Middle-Aged Patients with Type 2 Diabetes Mellitus in Relation with Gender

ABSTRACT

Objective: The aim of the present study was to determine the lipid profile in the elderly and middle-aged patients with Type 2 diabetes mellitus (DM) and its relation with gender.

Material and Methods: A total of 592 patients with Type 2 DM aged ≥60 years and 269 diabetic patients aged <60 years as middle-aged with initial admissions or patients with two months of antihyperlipidemic medicine pause were recruited from the internal medicine outpatient clinic during December 2012-March 2018. Demographic and biochemical data were collected retrospectively. Abnormal lipid levels were accepted as total-cholesterol >200 mg/dL, low density lipoprotein-cholesterol (LDL-C) ≥100 mg/dL, triglyceride (TG) ≥150 mg/dL, and high density lipoproteincholesterol (HDL-C) <50 in women <40 mg/dL in men.

Results: In total, 506 (85.4%) elderly and 248 (92.1%) middle-aged patients had one or more types of dyslipidemia. There were statistically significant differences in the frequencies of isolated high TG (x2=7.54, p=0.01) and combined two parameter dyslipidemia such as LDL-C ≥100 mg/dL & HDL-C <40 mg/dL & TG <150 mg/dL (x2=4.30, p=0.03) for men between elderly and middle-aged patients. Combined two-parameter dyslipidemia such as LDL-C ≥100 mg/dL, TG ≥150 mg/dL & HDL-C >50 mg/dL (x2=6.64, p=0.01), and isolated low HDL-C (x2=2.91, p=0.05) for women were found to be different between the elderly and middle-aged patients.

Conclusion: Hypertriglyceridemia with high LDL-C and isolated low HDL-C were more common in the elderly women than that in middle-aged women where isolated hypertriglyceridemia and combined high LDL-C with low HDL-C were higher in the elderly than the middle-aged for men.