Hormonally Active, Aggressive Gonadotropinoma with Increased Testicular Size: A Rare Case Report

We present a case report of a 32-year male who presented with pituitary macroadenoma with ini- tial presentation of visual disturbances in the form of decreased vision in the left eye followed by the right eye with no features suggestive of acromegaly, Cushing’s syndrome, and hypogonadism. Preoperative hormonal evaluation revealed high follicle-stimulating hormone, luteinizing hormone, and testosterone, rest of the hormonal profile was normal. The patient was subjected to craniotomy with tumor decompression which was complicated by transient Diabetes Insipidus (DI), central hypo- thyroidism, and hypocortisolism started on hormonal replacement, but there was little improve- ment in symptoms after surgery. The patient presented with deterioration of visual symptoms, and repeated magnetic resonance imaging revealed a similar lesion; the patient was again subjected to Transnasal transphenoidal surgery (TNTS) and radiotherapy. Immunohistochemistry of the tumor revealed positive staining for follicle-stimulating hormone and negative staining for adrenocortico- tropic hormone and growth hormone.

Cite this article as: Rasool A, Qadir A, Ashraf Ganie M, Sahar T, Rashid G. Hormonally active, aggressive gonadotropinoma with increased testicular size: A rare case report. Endocrinol Res Pract. 2023;27(3):177-179.