Endocrinology Research and Practice
Original Article

Factor V Leiden Mutation - an Unusual Cause of Hypopituitarism?

1.

Trabzon Numune Training and Research Hospital, Department of Endocrinology and Metabolism, Trabzon, Turkey

2.

Department of Internal Medicine, Division of Endocrinology, Metabolism and Nutrition, Istanbul Faculty of Medicine, Capa, 34390, Istanbul, Turkey

3.

University of İstanbul, İstanbul School of Medicine, Division of Endocrinology and Metabolism, İstanbul, Turkey

Endocrinol Res Pract 2000; 4: 33-35
Read: 1455 Downloads: 511 Published: 21 March 2022
ABSTRACT
Hypopituitarism is a disorder of diverse etiology that results in partial or total loss of pituitary functions. Here we report a 49-year-old female patient presenting with absence of peripheral pulses of the right upper extremity and anterior pituitary failure. She was initially diagnosed as Sheehan's syndrome in 1974 and Takayasu arteritis in 1990. But she was found to be positive for factor V Leiden mutation in 1990. We suggest that this mutation, which causes resistance to activated protein C and is an established risk factor for thrombosis, also is the cause for both the ischemic necrosis of the pituitary and subclavian artery occlusion in our case.
 
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EISSN 2822-6135