Endocrinology Research and Practice
Original Article

Evaluation of Additional Cardiovascular Risk Factors in Nondiabetic Obese Subjects


Istanbul University, Cerrahpaşa Medical Faculty, Department of Endocrinology and Metabolism, Istanbul, Turkey


Harran University, Medical Faculty, Department of Clinical Biochemistry, Şanlıurfa, Turkey


Harran University, Medical Faculty, Department of Internal Medicine, Şanlıurfa, Turkey

Endocrinol Res Pract 1998; 2: -
Read: 685 Published: 18 March 2022
Many studies have reported that obesity has several cardiovascular risk factors and itself is an independent risk factor for cardiovascular disease. In order to evaluate the relation between obesity, fat distribution and cardiovascular risk factors, 45 obese subjects (BMI >27 kg/m2, 21 abdominal type and 24 peripheral type, age 45.9± 15.4 years and 42.8 ± 11.3 years, respectively) and 29 nondlabetic, nonobese subjects (BMI < 27 kg/m2, age 42.2 ±16.6 years) were taken into the present study. Diabetic subjects were excluded because of the confounding effects of diabetes on cardiovascular disease. Plasma C-peptide level and diastolic blood pressure (dBP) were significantly higher in both abdominal and peripheral obesity groups than in nonobese group (c-peptide; 2.65 ±0.9 ng/ml, 2.65 ± 0.9 ng/ml and 1.87± 0.9 ng/ml, respectively (p< 0.01), dBP; 89.2± 8.8 mmHg, 87,8 T 8.7 mmHg and 81.1± 9.4, respectively (p< 0.05)). Systolic blood pressure (sBP) and plasma triglyceride level were also significantly higher in the abdominal obesity group than in nonobese group (sBP; 144.2± 21.6 vs. 129.7 ± 20.5 mmHg (p< 0.01), trigiyceride; 211.8 ±108.5 vs. 133.8 ± 86.5 mg/dl (p< 0.05). On the other hand, subjects with abdominal obesity showed a significant İncrease İn plasma triglyceride level compared with those with peripheral obesity (211.8 ± 108.5 vs. 134.7 ± 57.8 mg/dl (p< 0.05)). Although subjects with abdominal obesity tended to have higher mean fasting plasma glucose and total cholesterol, and lower plasma HDL cholesterol levels than peripherally obese and nonobese subjects, these values were not statistically significant. Other values such as urinary albumin / creatinine ratio, plasma LDL cholesterol, fructosamine, Hba1c were not different in all groups. These results showed that abdominal obesity has a closer relationship with cardiovascular risk factors. Therefore, we concluded that weight control should be an Integral part of the prevention of cardiovascular disease.
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