Endocrinology Research and Practice
Original Article

Endothelium-Dependent Hemostatic Factors in Women with Previous Gestational


Dokuz Eylül University Faculty of Medicine, Department of Endocrinology and Metabolism, İzmir, Turkey


Atatürk Training and Research Hospital, Clinic of Biochemistry, İzmir, Turkey


Dokuz Eylül University Faculty of Medicine, Department of Hematology, İzmir, Turkey

Endocrinol Res Pract 2016; 20: 43-47
DOI: 10.4274/tjem.3477
Read: 1197 Downloads: 342 Published: 01 June 2016


Purpose: Women with previous gestational diabetes mellitus (pGDM) are at increased risk for developing type 2 diabetes and cardiovascular disorders. The aim of this study was to investigate the levels of endothelium-dependent hemostatic factors in women with pGDM.
Material and Method: Eighty women with pGDM and 40 healthy women with no history of pGDM were included. The levels of glucose, insulin, c-peptide, lipids, C-reactive protein (CRP), and endothelium-dependent hemostatic factors, including plasminogen activator inhibitor-1 (PAI-1), von Willebrand factor, fibrinogen, tissue factor (TF), tissue plasminogen activator, and total tissue factor pathway inhibitor (TFPI), were measured.
Results: Women with pGDM had higher levels of CRP (p<0.001), fibrinogen (p=0.001), PAI-1 (p<0.001), TF (p=0.035), and total TFPI (p=0.009) compared to controls. Circulating levels of CRP and PAI-1 were significantly elevated in women with pGDM even after adjustment of body mass index (BMI) (CRP; p=0.022, and PAI-1; p=0.039). PAI-1 levels were positively correlated with BMI (r=0.374, p<0.001), waist-hip ratio (r=0.251, p=0.006), low density lipoprotein -cholesterol (r=0.246, p=0.007), triglyceride (r=0.296, p=0.001), fasting glucose (r=0.339, p<0.001), 2-h. plasma glucose (r=0.247, p=0.007), fasting insulin (r=0.334, p<0.001) and insulin resistance index (r=0.36, p<0.001), and negatively correlated with high-density lipoproteins-cholesterol (r=-0.420, p<0.001) and quantitative insulin sensitivity check index (r=-0.323, p<0.001).
Discussion: Our study shows that women with pGDM exhibit altered levels of endothelium-dependent hemostatic factors which seem to be associated with cardiovascular risk factors.


EISSN 2822-6135