Endocrinology Research and Practice
Original Article

Endothelial Function in Distinct Phenotypes of Obesity

1.

Kartal Dr. Lütfi Kırdar Training and Research Hospital, Clinic of Endocrinology and Metabolic Diseases, İstanbul, Turkey

2.

Kartal Dr. Lütfi Kırdar Training and Research Hospital, Clinic of Family Medicine, İstanbul, Turkey

Endocrinol Res Pract 2016; 20: 117-122
DOI: 10.4274/tjem.3600
Read: 1239 Downloads: 351 Published: 01 December 2016

ABSTRACT

Purpose: In our study, we aimed to determine whether metabolically healthy subjects with obesity would show endothelial dysfunction (ED) when compared with insulin-resistant subjects with obesity.
Material and Method: We enrolled 231 subjects with obesity (83% female) in this cross-sectional study. Brachial artery flow-mediated dilation was performed by Doppler ultrasonography and a standard 75-g oral glucose tolerance test were carried out in all participants. The subjects were stratified into tertiles based on their insulin sensitivity index values and defined as having insulin-resistant obesity if the values were in the lower tertile (n=77) or metabolically healthy obesity if the values were in the upper tertile (n=77). ED was defined as Δ flow-mediated dilation <4.5%.
Results: Metabolically healthy obesity and insulin-resistant obesity groups had similar ages (39±9 vs. 40±10 years; p=0.59) and body mass index (38±5 vs. 39±5 kg/m2; p=0.09). Waist circumference (101±11 vs. 106±13 cm; p=0.01), fasting blood glucose (87±9 vs. 97±13 mg/dL; p<0.001), diastolic blood pressure (79±11 vs. 82±12 mmHg; p=0.04) and uric acid levels (4.6±1.0 vs. 5.3±1.3 mg/dL; p<0.001) were lower in metabolically healthy obesity subjects, however, the incidence of ED was similar in both metabolically healthy obesity and insulin-resistant obesity subjects (80% vs. 71%; p=0.25, respectively).
Discussion: The incidence of ED, assessed by flow-mediated dilation, was similar both in metabolically healthy obesity and insulin-resistant obesity subjects. In this study, we showed that subjects with obesity as defined as metabolically healthy obesity might also show ED.

 

 

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