Endocrinology Research and Practice
Case Report

Diabetes Insipidus and Anterior Pituitary Insufficiency Due to Breast Cancer Metastasis


Ankara Numune Training and Research Hospital, Clinic of Endocrinology and Metabolism, Ankara, Turkey


Gazi University Faculty of Medicine, Department of Radiology, Ankara, Turkey


Hitit University Faculty of Medicine, Department of Endocrinology and Metabolism, Çorum, Turkey

Endocrinol Res Pract 2016; 20: 19-21
DOI: 10.4274/tjem.2902
Read: 1223 Downloads: 341 Published: 01 March 2016


Metastases from breast cancer to the pituitary gland are uncommon. We present a 35-year-old woman with diabetes insipidus and anterior pituitary insufficiency resulting from breast cancer metastases to the pituitary gland. The patient presented with reduced consciousness, fatigue, polyuria, and polydipsia. Hypernatremia (sodium: 154 mmol/L), hypostenuria (urine density: 1001), and hypopituitarism were present on laboratory evaluation. Magnetic resonance imaging (MRI) revealed heterogeneous pituitary gland, thickened pituitary stalk (8mm), and loss of normal hyperintense signal of the posterior pituitary. Based on the clinical, laboratory, and MRI findings, the patient was diagnosed with diabetes insipidus and anterior pituitary insufficiency due to pituitary metastases from breast cancer. She received desmopressin, L-thyroxine, and prednisolone, which resulted in improvement of her symptoms and laboratory results. The patient, who also received Gamma Knife radiosurgery and chemotherapy, died six months later due to disseminated metastases. Although pituitary metastasis is rare, it should be kept in mind in patients with breast cancer since early detection and treatment can improve symptoms of patients.


EISSN 2822-6135