Determination of the Frequencies of Various Thyroid Autoantibodies in Autoimmune Thyroid Diseases and Evaluation of Their Relationship with Sonographic Findings: A Single-Center Study

Objective: The frequency of thyroid autoantibodies in autoimmune thyroid disease is known to vary between countries. We aimed to determine the frequency of autoantibody positivity and the correlation between sonographic findings and autoantibodies in autoimmune thyroid disease.

Methods: Laboratory findings and ultrasound findings of 490 patients with Hashimoto’s thyroiditis and 225 patients with Graves’ disease were retrospectively enrolled from a tertiary center.

Results: Anti-thyroid peroxidase and anti-thyroglobulin positivity were 90.2% and 60.2% in Hashimoto’s thyroiditis patients, respectively. Anti-thyroglobulin titers were significantly higher in males (P < .01). Mean thyroid volume of Hashimoto’s thyroiditis patients was 10.5 ± 6.9 mL and 11.6% of patients had atrophic thyroiditis (30 U/L, 10-30 U/L, 30 U/L was found to be significantly higher than the others (P=.049).

Conclusion: In conclusion, the most prevalent antibody detected in Hashimoto’s and Graves’ disease is anti-thyroid peroxidase and TSH receptor antibody, respectively, in Turkish patients. Furthermore, a significant relation was found between anti-thyroid peroxidase positivity and anti-thyroid peroxidase titer and the degree of sonographic heterogeneity.

Cite this article as: Bağcı Akçeşme A, Avcı Merdin F, Bahçecioğlu AB, Erdoğan MF. Determination of the frequencies of various thyroid autoantibodies in autoimmune thyroid diseases and evaluation of their relationship with sonographic findings: A single-center study. Turk J Endocrinol Metab. 2022;26(4):191-196.