Determination of Serum Thyroid Hormones and Electrolytes in Hypothyroid and Hyperthyroid Females-A Case Control Study in Lahore, Pakistan

ABSTRACT

Objective: This study aimed to determine the correlation between serum electrolytes and TSH in patients with hypothyroidism and hyperthyroidism.

Material and Methods: A total of 160 (80 hypothyroid and 80 hyperthyroid) patients and 80 age and gender matched controls were enrolled in this study, which was performed between September 2017-February 2018. Of the venous blood, 3 mL was collected from each study participant, for measurement of thyroid hormones (T3, T4, and TSH) and electrolytes (Na, K and Ca).

Results: Serum calcium was observed to be significantly high in hyperthyroid patients as compared to their controls. Serum sodium and potassium levels were not found to differ significantly among hyperthyroid and hypothyroid patients compared to that in their controls. Patients with hyperthyroidism showed significant negative correlation of TSH with calcium and a non-significant positive correlation with sodium and potassium. The correlation of TSH with calcium was positive while that with potassium and sodium was negative in hypothyroid patients, though this co-relation was statistically non-significant.

Conclusion: This study found high serum calcium levels in hyperthyroid patients. A significantly negative correlation was found between TSH and calcium level in hyperthyroidism.