Correlations of Serum Cu+2, Zn+2, Mg+2 and HbA1c in Type 2 and Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus (DM) is one of the most frequently seen. Type 2 DM shows identical patophysiological features with Type 1 DM but differs in etiology. There are lots of studies in the area of both types of DM which are influencing body by metabolic and oxidative stress. In this study serum Cu, Zn and Mg levels are determined in three patient groups (Type 1 DM, obese Type 2 DM, non-obese Type 2 DM) and discussed the relationships with serum cholesterol,trigliserid, glucose and blood HbA1C levels. Study groups evaluated as 21 healty person, 26 non-obese Type 2 DM patients (Body mass index30), 18 Type 1 DM patients While we didn’t find any correlation between parameters of obese Type 2 DM patients, there was slightly negative correlation (r=-0,521, p0,05). The results showed that the determination of serum Zn level is not enough to assess the oxidative stress in DM. Because of the probable lacking of serum Zn/Cu antagonism, serum Cu and Mg levels should be determined. In DM, blood HbA1C levels change the profile of trace elements so can be used to assess tha degree of oxidative and metabolic stress.