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ABSTRACT
In the measurement of insulin sensitivity, intravenous insulin tolerance test (IVITT) has been shown to have a high correlation with the euglycemic hyperinsulinemic clamp method. We compared IVITT with levels of plasma Insulin/Glucose ratio (IGR), levels of plasma Insulin/C-peptid ratio (ICR), fasting and 1-h post load insulin levels in 58 nondiabetic obese subjects (Mean BM1: 28.8±1.6 kg/m2, age: 42.8±8.5 years). The glucose levels were determined at 3 min intervals for 15 min after insulin injection. insulin sensitivity was estimated with blood glucose disappearance rate (KITT).KITT 3.51±2.38 % min-1; fasting and post load IGR 35±20, 139±74 pM/mM; fasting and post load ICR 0.14±0.13, 0.25±0.15 pM; fasting and postload 1-h insulin levels were 124.2±48, 882±364 pM, respectively. KITT correlated only with fasting insulin level (r=0.52, p<0.05) and fasting IGR (r= -0.47, p<0.05). Fasting insulin level correlated with 1-h post load insulin level (r=0.58, p<0.05). Fasting IGR correlated with 1-h post load IGR (r=0.55, p<0.05) and fasting ICR (r=0.65, p<0.05). Fasting ICR correlated with 1 -h post load ICR (r=0.67, p<0.001). As a result fasting/postglucose 1 -h insulinaemia has been found very useful in measuring insulin sensitivity, practically. But the ratio of insulinaemia/glycaemia (IGR) appeared to be simple and better method in terms of good correlation with KITT.
In the measurement of insulin sensitivity, intravenous insulin tolerance test (IVITT) has been shown to have a high correlation with the euglycemic hyperinsulinemic clamp method. We compared IVITT with levels of plasma Insulin/Glucose ratio (IGR), levels of plasma Insulin/C-peptid ratio (ICR), fasting and 1-h post load insulin levels in 58 nondiabetic obese subjects (Mean BM1: 28.8±1.6 kg/m2, age: 42.8±8.5 years). The glucose levels were determined at 3 min intervals for 15 min after insulin injection. insulin sensitivity was estimated with blood glucose disappearance rate (KITT).KITT 3.51±2.38 % min-1; fasting and post load IGR 35±20, 139±74 pM/mM; fasting and post load ICR 0.14±0.13, 0.25±0.15 pM; fasting and postload 1-h insulin levels were 124.2±48, 882±364 pM, respectively. KITT correlated only with fasting insulin level (r=0.52, p<0.05) and fasting IGR (r= -0.47, p<0.05). Fasting insulin level correlated with 1-h post load insulin level (r=0.58, p<0.05). Fasting IGR correlated with 1-h post load IGR (r=0.55, p<0.05) and fasting ICR (r=0.65, p<0.05). Fasting ICR correlated with 1 -h post load ICR (r=0.67, p<0.001). As a result fasting/postglucose 1 -h insulinaemia has been found very useful in measuring insulin sensitivity, practically. But the ratio of insulinaemia/glycaemia (IGR) appeared to be simple and better method in terms of good correlation with KITT.