Coexistence of Primary Mucosa-Associated Lymphoid Tissue Lymphoma of Thyroid and Papillary Thyroid Microcarcinoma in a Background of Hashimoto’s Thyroiditis

ABSTRACT

Papillary thyroid carcinoma (PTC) is the most common endocrine cancer; however, extranodal marginal zone lymphoma of the mucosa-associated lymphoid tissue (MALT) of the thyroid gland is quite rare. The comorbid condition of both cancers is an infrequent event. In the present study, we report a 65-year-old woman, who underwent a thyroid ultrasound examination due to palpable thyroid nodules. The reports of the thyroid ultrasound revealed thyroiditis and the presence of multiple nodules on both lobes. Although the results revealed that biopsies were benign, total thyroidectomy was performed due to the presence of multiple nodules that may become difficult for the subsequent follow-up. Histopathological analysis exhibited the presence of papillary thyroid microcarcinomas in two foci, Hashimoto’s thyroiditis accompanied with MALT lymphoma. No metastasis was found in postoperative computed tomography (CT) scans. However, bone marrow biopsy indicated uniform marginal zone lymphoma. From the result, it can be concluded that PTC and Primary Thyroid Lymphoma (PTL) may be associated with Hashimoto’s thyroiditis, and for both the diseases multimodal approach is required.