Endocrinology Research and Practice
Case Report

Co-existence of Insulin Dependent Diabetes and Graves’ Disease in a Patient with Down Syndrome - Case Report

1.

Şanlıurfa Training and Research Hospital, Department of Internal Medicine, Division of Endocrinology and Metabolism, Şanlıurfa, Turkey

Endocrinol Res Pract 2010; 14: 17-19
Read: 1932 Downloads: 627 Published: 01 March 2010

Abstract
Down's syndrome is the most common genetic disorder. It is well established that there is an increased risk of autoimmune endocrine diseases in Down's syndrome. Defect of a gene located on chromosome 21q22.3 causes autoimmune polyglandular syndrome type 1 and this might be related with susceptibility to autoimmune diseases in patients with Down's syndrome. We reported a 20-year-old male with Down's syndrome who was brought to emergency room by his family and had a diagnose of diabetic ketoacidosis and Graves' disease. Underlying mechanisms in co-existing of autoimmune diseases in Down's syndrome, management of such patients and the importance of making the family to be aware of the symptoms of possible subsequent components of the autoimmune polyglandular syndrome are discussed. 

 

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EISSN 2822-6135