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ABSTRACT
Thyrotropin-secreting pituitary adenomas are rare tumors, and prevalence is about one case per million. Normal or elevated thyrotropin levels in hyperthyroid patients are characteristic of TSH-secreting pituitary adenoma. Because TSH-secreting pituitary tumors are uncommon, subjects with TSH-omas are often misdiagnosed as having Graves disease, and misdiagnosis may leads to enlargement of tumor size. We present a patient with thyrotropin-secreting pituitary adenoma misdiagnosed as Graves disease. The patient has high T3, FT3, FT4 and TSH, and she has a pituitary microadenoma ( 9 mm). Once the inappropriate secretion of TSH is established, the differential diagnosis between TSH-secreting tumor and resistance to thyroid hormone must be made.
Thyrotropin-secreting pituitary adenomas are rare tumors, and prevalence is about one case per million. Normal or elevated thyrotropin levels in hyperthyroid patients are characteristic of TSH-secreting pituitary adenoma. Because TSH-secreting pituitary tumors are uncommon, subjects with TSH-omas are often misdiagnosed as having Graves disease, and misdiagnosis may leads to enlargement of tumor size. We present a patient with thyrotropin-secreting pituitary adenoma misdiagnosed as Graves disease. The patient has high T3, FT3, FT4 and TSH, and she has a pituitary microadenoma ( 9 mm). Once the inappropriate secretion of TSH is established, the differential diagnosis between TSH-secreting tumor and resistance to thyroid hormone must be made.