Endocrinology Research and Practice
Olgu Sunumu

Hypoparathyroidism: A Rare Manifestation of Metastatic Breast Carcinoma


Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


Department of Internal Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Endocrinol Res Pract 2023; 27: 89-92
DOI: 10.5152/erp.2023.223960
Okunma: 578 İndirilme: 246 Online Yayın Tarihi: 24 Nisan 2023

Hypocalcemia is a disorder that may develop in cancer patients as a result of chemotherapeutic agents or tumor lysis syndrome. In rare situations, hypocalcemia may be due to hypoparathyroidism associated with bone-metastatic malignancy. Here, we report a 54-year-old woman with a known case of breast cancer, who presented to the hospital with numbness and paresthesia of the distal extremities 1 year after mastectomy and chemotherapy. She had low plasma calcium and parathyroid hormone levels, as well as a high serum phosphate level. Finally, she was treated with calcium gluconate infusion and calcitriol with a diagnosis of primary hypoparathyroidism. Overall, this case emphasizes the importance of measuring serum calcium levels in patients with metastatic bone carcinoma since this could affect their symptoms. Moreover, we should consider the probability of hypoparathyroidism in the differential diagnosis of hypocalcemic symptoms, even in patients with known malignancy.

Cite this article as: Aboutorabi R, Akbari-Rad M, Ataei Azimi S. Hypoparathyroidism: A rare manifestation of metastatic breast carcinoma. Endocrinol Res Pract. 2023;27(2):89-92.

EISSN 2822-6135