Endocrinology Research and Practice
Orijinal Araştırma

Effect of Sensor-Augmented Patch Pump with Predictive Low-Glucose Suspend Feature Compared to Multiple-Dose Insulin in Patients with Brittle Type 1 Diabetes


Department of Endocrinology and Metabolism, İstanbul University, Faculty of Medicine, İstanbul, Turkey


Department of Endocrinology and Metabolism, Medical Park Hospital Gaziosmanpaşa, İstanbul, Turkey


Department of Nutrition and Dietetics, Hacettepe University, Faculty of Medicine, Ankara, Turkey


Department of Endocrinology and Metabolism, Demiroğlu Bilim University, Istanbul, Turkey

Endocrinol Res Pract 2023; 27: 44-47
DOI: 10.5152/erp.2023.22130175
Okunma: 388 İndirilme: 148 Online Yayın Tarihi: 24 Nisan 2023

Objective: The conventional approach to brittle diabetes is the treatment of underlying causes and optimization with multiple-dose insulin injections. The goal of multiple-dose insulin therapy is to exactly mimic physiological insulin secretion; however, it often results in hypoglycemia. This study investigates the effectiveness of continuous subcutaneous insulin infusion therapy with a patch pump with the sensor augmented with predictive low-glucose suspend algorithm system in patients with uncontrolled type 1 diabetes who were treated with multiple-dose insulin and have high glycated hemoglobin values.

Methods: The data of patients whose glycemic control could not be achieved with multiple-dose insulin therapy and who were switched to sensor-augmented tubeless pump with predictive lowglucose suspend feature (Medtrum A7+ TouchCare patch pump and integrated A7+ continuous glucose monitoring system) were analyzed retrospectively.

Results: A total of 16 patients (male: 9; 56.3%) were included. After 3 months of the sensor-augmented pump with predictive low-glucose suspend treatment, patients’ median (interquartile range) glycated hemoglobin level decreased to 7.55 (1.43) from 9.20 (3.55) (P=.008). Time below 56 mg/dL was 0.34%, time between 56 and 70 mg/dL was 1.01%, time between 70 and 180 mg/dL was 72.90%, time above 180 mg/dL was 25.67%, time between 70and 250 mg/dL was 95.98%, and time above 250 mg/dL was 2.76%.

Conclusions: A pump system with predictive low-glucose suspend feature improves glycemic targets in patients with brittle uncontrolled type 1 diabetes without the expense of hypoglycemia compared to multiple-dose insulin treatment.

Cite this article as: Yılmaz MT, Telci Çaklılı O, Hacişahinoğulları H, Çakmak R, Şahiner E, Keskin E. Effect of sensor-augmented patch pump with predictive low-glucose suspend feature compared to multiple-dose insulin in patients with brittle type 1 diabetes. Endocrinol Res Pract. 2023;27(2):44-47.

EISSN 2822-6135