Oxidative Stress Markers in Metabolic Syndrome

ABSTRACT

Objective: The aim of this study was to determine the significance of serum ischemia-modified albumin (IMA) level and oxidative stress markers (total antioxidant status-TAS and total oxidant status-TOS) in metabolic syndrome (MetS) group with and without diabetes mellitus and to compare serum IMA level, TAS and TOS in MetS group and healthy control participants.
Research design and methods: We studied 52 MetS patients (mean age: 56.74±12.75 years) and 36 control subjects (mean age: 26.47±6.52 years). The presence of MetS was diagnosed according to the National Cholesterol Education Program-Adults Treatment Panel III (NCEP-ATP III). Serum IMA, TAS, TOS and biochemical parameters were measured in all participants.
Results: The mean levels of fasting blood glucose (FBG), total cholesterol, triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-sensitivity C-reactive protein (hs-CRP), body mass index (BMI), and waist circumference were significantly higher in the MetS group than in the control group. Although metabolic parameters were significantly higher in the MetS group, the mean IMA level, TAS and TOS were similar between the groups (p>0.05). However, in the MetS group, the age-adjusted mean IMA level was significantly higher in diabetic than nondiabetic patients (0.27±0.011 versus 0.24±0.015; p=0.048). The mean TAS value was found to be highest in nondiabetic MetS patients.
Conclusion: Absence of difference between diabetic and control patients may be caused by higher IMA levels due to higher metabolic rate in younger participants. Presence of diabetes mellitus in MetS patients was associated with higher IMA levels free from age and lower TAS levels.