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Endocrinology Research and Practice
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Published Online: September 1, 2026
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Copyright © 2026 Endocrinology Research and Practice
Afruz Babayeva
Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Türkiye
Meriç Coşkun
Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Türkiye
Öykü Öztürk
Department of Neurosurgery, Gazi University Faculty of Medicine, Ankara, Türkiye
Selen Yılmaz
Hacettepe University Vocational School of Social Sciences, Ankara, Türkiye
Fidan Yusifova
Department of Internal Medicine, Gazi University Faculty of Medicine, Ankara, Türkiye
Ethem Turgay Cerit
Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Türkiye
Mehmet Muhittin Yalçın
Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Türkiye
Alev Eroğlu Altınova
Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Türkiye
Füsun Toruner
Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Türkiye
Mehmet Ayhan Karakoç
Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Türkiye
Emrah Çeltikçi
Department of Neurosurgery, Gazi University Faculty of Medicine, Ankara, Türkiye
Müjde Aktürk
Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Türkiye
Babayeva, A., Coşkun, M., Öztürk, Öykü, Yılmaz, S., Yusifova, F., Cerit, E. T., … Aktürk, M. (2026). The Evaluation of the Predictive Value of Early Postoperative Biochemical Parameters for Remission in Patients with Acromegaly. Endocrinology Research and Practice. https://doi.org/10.5152/erp.2026.26985
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Abstract
Objective: This study aimed to evaluate the predictive value of growth hormone (GH), insulin-like growth factor-1 (IGF-1), calcium (Ca), and phosphorus (P) levels in the first 2-4 days after surgery for achieving biochemical remission in patients with newly diagnosed acromegaly.
Methods: This retrospective cohort study included patients with acromegaly who underwent surgery. Preoperative and early postoperative days 2-4 (POD2-4), 3rd month, and 12th month serum levels of GH, IGF-1, Ca, and P were obtained. Age-normalized IGF-1 levels defined remission at 3-6 months, and patients were grouped accordingly.
Results: Biochemical remission was achieved in 44 of 68 patients (64.7%). Preoperative GH, IGF-1, and Ca were significantly higher in the non-remission group (all P < .05), while P did not differ. In POD2-4, all parameters, including P, were significantly higher in the non-remission group (P < .05). Receiver operating characteristic (ROC) analysis showed that a GH ≤1.28 in POD2-4 (AUC = 0.858, sensitivity: 0.74, specificity: 0.88) and a ≥45.29% decrease in IGF-1 from preoperative values (AUC = 0.816; sensitivity: 0.73, specificity: 0.79) predicted remission. At 12 months, GH and IGF-1 remained significantly different, whereas Ca and P did not (P = .67 and P = .20).
Conclusion: In patients with acromegaly, GH, IGF-1, Ca, and P levels measured in the first 2-4 days after surgery were found to be significantly lower in the remission group than in those who did not achieve remission. Postoperative GH levels and the percentage decrease in IGF-1 levels were associated with remission and may help with early risk stratification.
Cite this article as: Babayeva A, Coskun M, Ozturk O, et al. The evaluation of the predictive value of early postoperative biochemical parameters for remission in patients with acromegaly. Endocrinol Res Pract. Published online September 1, 2026. doi: 10.5152/erp.2026.26985
Article Info
History
Published Online
September 1, 2026
License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Copyright
Copyright (c) 2026 Endocrinology Research and Practice
Affiliations
Afruz Babayeva
Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Türkiye
Meriç Coşkun
Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Türkiye
Öykü Öztürk
Department of Neurosurgery, Gazi University Faculty of Medicine, Ankara, Türkiye
Selen Yılmaz
Hacettepe University Vocational School of Social Sciences, Ankara, Türkiye
Fidan Yusifova
Department of Internal Medicine, Gazi University Faculty of Medicine, Ankara, Türkiye
Ethem Turgay Cerit
Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Türkiye
Mehmet Muhittin Yalçın
Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Türkiye
Alev Eroğlu Altınova
Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Türkiye
Füsun Toruner
Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Türkiye
Mehmet Ayhan Karakoç
Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Türkiye
Emrah Çeltikçi
Department of Neurosurgery, Gazi University Faculty of Medicine, Ankara, Türkiye
Müjde Aktürk
Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Türkiye
Cite this Article
Babayeva, A., Coşkun, M., Öztürk, Öykü, Yılmaz, S., Yusifova, F., Cerit, E. T., … Aktürk, M. (2026). The Evaluation of the Predictive Value of Early Postoperative Biochemical Parameters for Remission in Patients with Acromegaly. Endocrinology Research and Practice. https://doi.org/10.5152/erp.2026.26985
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